Why Gly-kit?

Gly-Kit is a unique platform which allows you to use enzymes to add sugars to small molecules (glycosylation).

 

Any small molecule can be rapidly screened against more than 380 diverse glycosyltransferase enzymes (UGTs).

Glycosylation can: 

  • Make compounds more soluble – improving GI absorption and enabling better formulations

  • Improve a compound’s ADMET profile – changing tissue distribution, cell uptake etc.

  • Improve enzymatic or physical stability

  • Reduce toxicity – improving the safety window in pharmaceuticals, enabling higher titres in microbial production, etc.

  • Change organoleptic properties – making them sweeter, less bitter or changing the flavour profile

  • Allow novel molecules to be created – with potentially novel utilities and refreshed IP

  • Provide a fully scalable production platform at low cost

 

Two screening systems can be used with the platform:

  1. A colorimetric assay that allows for quick identification of which enzyme(s) glycosylate a molecule.

  2. HPLC/MS-based, giving more quantitative results and at least partial structure elucidation.​

We can provide UGT sequences of the enzyme(s) responsible for the glycosylation as  well as the associated expression systems.

 

Don't see specifically what you are working on right now? Email us and we can assist - we will be releasing additional applications and uses in the coming months.

We realize that this may be your first step in determining if Gly-Kit will be able to assist you in your current project. 

 

If you were intrigued by our click menu statements on the home page, we encourage you to reach out to us for additional information that can assist with your decision. 

 

We are happy to assist you in determining if Gly-Kit is the right fit.  

Contact Us

One of our team will reach out to you shortly to assist you in any questions you may have about GLY-KIT. 

River Stone Biotech ApS
Fruebjergvej 3
2100 Copenhagen
Denmark 

Call

EU: +353 (0)87 184 1966

USA: +1 (703) 999-3537

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